Role of threonine 342 in helix 7 of the 5-hydroxytryptamine type 1D receptor in ligand binding: an indirect mechanism for receptor selectivity.

Article

Role of threonine 342 in helix 7 of the 5-hydroxytryptamine type 1D receptor in ligand binding: an indirect mechanism for receptor selectivity.

Molecular pharmacology - 1 Oct 1993

Smolyar A, Osman R

Abstract excerpt

Recent mutations of the 5-hydroxytryptamine (5-HT)1B and 5-HT1D receptor subtypes suggest that a threonine in the seventh transmembrane helix may be responsible for the selectivity of these receptors. A molecular dynamics simulation of a three-dimensional model of the 5-HT1D receptor interacting...

Topics

Binding Sites
Humans
Hydrogen Bonding
Ligands
Macromolecular Substances
Models, Chemical
Mutation
Protein Structure, Secondary
Receptors, Serotonin
Thermodynamics
Threonine

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