Article
The head involution defective gene of Drosophila melanogaster functions in programmed cell death.
Genes & development - 15 Jul 1995
Grether M E, Abrams J M, Agapite J, White K, Steller H
Abstract excerpt
Deletions of chromosomal region, 75C1,2 block virtually all programmed cell death (PCD) in the Drosophila embryo. We have identified a gene previously in this interval, reaper (rpr), which encodes an important regulator of PCD. Here we report the isolation of a second gene in this region, head involution defective (hid), which plays a similar role in PCD. hid mutant embryos have decreased levels of cell death and...
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