A screen for dominant modifiers of the irreC-rst cell death phenotype in the developing Drosophila retina.

doi:10.1093/genetics/156.1.205

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Article

A screen for dominant modifiers of the irreC-rst cell death phenotype in the developing Drosophila retina.

Genetics - 1 Sept 2000

Tanenbaum S B, Gorski S M, Rusconi J C, Cagan R L

Abstract excerpt

Programmed cell death (PCD) in the Drosophila retina requires activity of the irregular chiasmC-roughest (irreC-rst) gene. Loss-of-function mutations in irreC-rst block PCD during retinal development and lead to a rough eye phenotype in the adult. To identify genes that interact with irreC-rst and may be involved in PCD, we conducted a genetic screen for dominant enhancers and suppressors of the adult rough eye...

Topics

Alleles
Animals
Apoptosis
Cell Adhesion Molecules, Neuronal
Chromosome Mapping
Crosses, Genetic
Drosophila
Drosophila Proteins
Enhancer Elements, Genetic
Eye Proteins
Female
Genes, Insect
Genetic Complementation Test
Insect Proteins
Male
Mutation
Phenotype
Retina

Source

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Identifiers

PMID: 10978286
DOI: 10.1093/genetics/156.1.205
PMCID: PMC1461222

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