Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of actin cytoskeleton in lymphocytes: PKC-delta disrupts IL-3-induced membrane ruffles downstream of Rac1.

Journal of cellular physiology - 1 May 1999

Romanova L Y, Alexandrov I A, Blagosklonny M V, Nordan R P, Garfield S, Acs P, Nguyen P, Trepel J, Blumberg P M, Mushinski J F

Abstract excerpt

In the murine pre-B lymphoid cell line Baf3, the presence of IL-3 is required for the formation of membrane ruffles that intensely stain for actin and are responsible for the elongated cell phenotype. Withdrawal of IL-3 dissolves ruffled protrusions and converts the cell phenotype to round. Flow cytometric analysis of the cell shape showed that an inactive analog of Rac1 but not inactive RhoA or inactive cdc42...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Size
Share to Cytochalasin D

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-3

Share to Maleimides

Share to Protein Kinase C

Share to Protein Kinase C-delta

Share to rac GTP-Binding Proteins

Share to Tetradecanoylphorbol Acetate

Source

Identifiers

PMID: 10199555
DOI: 10.1002/(SICI)1097-4652(199905)179:2<157::AID-JCP6>3.0.CO;2-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of actin cytoskeleton in lymphocytes: PKC-delta disrupts IL-3-induced membrane ruffles downstream of Rac1.PMID 10199555Read ↗

Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration.Semantic proximity Read ↗

Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells.Semantic proximity Read ↗

Phosphorylation of paxillin tyrosines 31 and 118 controls polarization and motility of lymphoid cells and is PMA-sensitive.Semantic proximity Read ↗

3BP-1, an SH3 domain binding protein, has GAP activity for Rac and inhibits growth factor-induced membrane ruffling in fibroblasts.Semantic proximity Read ↗

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling.Semantic proximity Read ↗

To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front.Semantic proximity Read ↗

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras.Semantic proximity Read ↗

Role of phosphoinositide 3OH-kinase in autocrine transformation by PDGF-BB.Semantic proximity Read ↗

Investigation of the signal transduction pathways involved in the induction of T-lymphocyte motilitySemantic proximity Read ↗

Cell type-specific regulation of RhoA activity during cytokinesis.Semantic proximity Read ↗

Reversible bleb formation in mast cells stimulated with antigen is Ca2+/calmodulin-dependent and bleb size is regulated by ARF6.Semantic proximity Read ↗

Inhibition of protein kinase C results in a switch from a non-motile to a motile phenotype in diverse human lymphocyte populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.