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Article

Regulation of STAT3 by direct binding to the Rac1 GTPase.

Science (New York, N.Y.) - 6 Oct 2000

Simon A R, Vikis H G, Stewart S, Fanburg B L, Cochran B H, Guan K L

Abstract excerpt

The signal transducers and activators of transcription (STAT) transcription factors become phosphorylated on tyrosine and translocate to the nucleus after stimulation of cells with growth factors or cytokines. We show that the Rac1 guanosine triphosphatase can bind to and regulate STAT3 activity....

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Source

Identifiers

PMID: 11021801
DOI: 10.1126/science.290.5489.144

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11021801-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Regulation of STAT3 by direct binding to the Rac1 GTPase.PMID 11021801Read ↗

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