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Article

Regulation of STAT3 by direct binding to the Rac1 GTPase.

Science (New York, N.Y.) - 6 Oct 2000

Simon A R, Vikis H G, Stewart S, Fanburg B L, Cochran B H, Guan K L

Abstract excerpt

The signal transducers and activators of transcription (STAT) transcription factors become phosphorylated on tyrosine and translocate to the nucleus after stimulation of cells with growth factors or cytokines. We show that the Rac1 guanosine triphosphatase can bind to and regulate STAT3 activity. Dominant negative Rac1 inhibited STAT3 activation by growth factors, whereas activated Rac1 stimulated STAT3...

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Source

Identifiers

PMID: 11021801
DOI: 10.1126/science.290.5489.144

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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