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Article

Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling.

The Journal of biological chemistry - 16 Jan 2004

Fairlie W Douglas, Uboldi Alessandro D, McCoubrie Joanne E, Wang Chunxiao C, Lee Erinna F, Yao Shenggen, De Souza David P, Mifsud Sandra, Metcalf Donald, Nicola Nicos A, Norton Raymond S, Baca Manuel

Abstract excerpt

Leukemia inhibitory factor (LIF)-induced cell signaling occurs following sequential binding to the LIF receptor alpha-chain (LIFR), then to the gp130 co-receptor used by all members of the interleukin-6 family of cytokines. By monovalently displaying human LIF on the surface of M13 phage and randomizing clusters of residues in regions predicted to be important for human LIFR binding, we have identified mutations,...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-6

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Share to Nuclear Magnetic Resonance, Biomolecular

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Source

Identifiers

PMID: 14585833
DOI: 10.1074/jbc.M310103200

Genes

LIFR
LIF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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