Article
A naturally occurring growth hormone receptor mutation: in vivo and in vitro evidence for the functional importance of the WS motif common to all members of the cytokine receptor superfamily.
Molecular endocrinology (Baltimore, Md.) - 1 Jun 1993
Duriez B, Sobrier M L, Duquesnoy P, Tixier-Boichard M, Decuypere E, Coquerelle G, Zeman M, Goossens M, Amselem S
Abstract excerpt
To obtain an animal model for studying the role of the GH receptor (GHR) in growth and development, we analyzed a sex-linked dwarf (SLD) chicken strain (Leghorn) which exhibits phenotype similarities with a human genetic growth disorder, an autosomal recessive GH resistance condition (Laron dwarfism). Having previously demonstrated the responsibility of the human GHR gene in the Laron phenotype, we focused our...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.