Amino acid substitutions in the V3 loop are responsible for adaptation to growth in transformed T-cell lines of a primary human immunodeficiency virus type 1.

doi:10.1006/viro.1995.1367

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Article

Amino acid substitutions in the V3 loop are responsible for adaptation to growth in transformed T-cell lines of a primary human immunodeficiency virus type 1.

Virology - 10 Jul 1995

Harrowe G, Cheng-Mayer C

Abstract excerpt

A T-cell-line-tropic, syncytium-inducing, sCD4- and serum neutralization-sensitive variant (R3H) of the macrophage-tropic, non-syncytium-inducing, sCD4- and serum neutralization-resistant molecular clone HIV-1SF162 was obtained by passage through the T-cell line HUT 78. Sequence analyses of the V1-V5 regions of envelope gp120 of the variant R3H revealed amino acid substitutions in the V3 (amino acids 307, 312)...

Topics

Adaptation, Physiological
Amino Acids
Antibodies, Monoclonal
Antibodies, Viral
CD4 Antigens
Cell Line, Transformed
HIV Envelope Protein gp120
HIV-1
Humans
Immune Sera
Leukocytes, Mononuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macrophages

Mutation

Neutralization Tests

Peptide Fragments

Recombinant Proteins

Sequence Analysis, DNA

Serial Passage

Source

Open in PubMed

Identifiers

PMID: 7618285
DOI: 10.1006/viro.1995.1367

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7618285-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Amino acid substitutions in the V3 loop are responsible for adaptation to growth in transformed T-cell lines of a primary human immunodeficiency virus type 1.PMID 7618285Read ↗

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