Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

T-cell line adaptation of human immunodeficiency virus type 1 strain SF162: effects on envelope, vpu and macrophage-tropism.

The Journal of general virology - 1 Dec 2000

Dejucq Nathalie, Simmons Graham, Clapham Paul R

Abstract excerpt

Changes in co-receptor-use by human immunodeficiency virus type 1 (HIV-1) strains are relatively rare in vivo. Here we describe two variants derived from the CCR5-using strain SF162, selected for replication in the C8166 T-cell line. Amino acid substitutions in the V3 loop conferred CXCR4-use; however, the loss of macrophage-tropism by one variant was due to a single mutation in the start codon of vpu. We discuss...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon, Initiator
Share to DNA, Recombinant
Share to HIV

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Envelope Protein gp160

Share to Human Immunodeficiency Virus Proteins

Share to Receptors, CXCR4

Share to Serial Passage

Share to Viral Regulatory and Accessory Proteins

Source

Identifiers

PMID: 11086121
DOI: 10.1099/0022-1317-81-12-2899

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

T-cell line adaptation of human immunodeficiency virus type 1 strain SF162: effects on envelope, vpu and macrophage-tropism.PMID 11086121Read ↗

Evolution of CXCR4-using human immunodeficiency virus type 1 SF162 is associated with two unique envelope mutations.Semantic proximity Read ↗

Envelope V3 amino acid sequence predicts HIV-1 phenotype (co-receptor usage and tropism for macrophages).Semantic proximity Read ↗

CCR5 coreceptor usage of non-syncytium-inducing primary HIV-1 is independent of phylogenetically distinct global HIV-1 isolates: delineation of consensus motif in the V3 domain that predicts CCR-5 usage.Semantic proximity Read ↗

Derivation and characterization of a simian immunodeficiency virus SIVmac239 variant with tropism for CXCR4.Semantic proximity Read ↗

Amino acid substitutions in the V3 loop are responsible for adaptation to growth in transformed T-cell lines of a primary human immunodeficiency virus type 1.Semantic proximity Read ↗

Alternative Coreceptor Requirements for Efficient CCR5- and CXCR4-Mediated HIV-1 Entry into MacrophagesSemantic proximity Read ↗

Simian immunodeficiency virus variants with differential T-cell and macrophage tropism use CCR5 and an unidentified cofactor expressed in CEMx174 cells for efficient entry.Semantic proximity Read ↗

Concordant utilization of macrophage entry coreceptors by related variants within an HIV type 1 primary isolate viral swarm.Semantic proximity Read ↗

Evaluation of genotypic tropism prediction tests compared with in vitro co-receptor usage in HIV-1 primary isolates of diverse subtypes.Semantic proximity Read ↗

Effects of vpu start-codon mutations on human immunodeficiency virus type 1 replication in macrophages.Semantic proximity Read ↗

Co-receptor usage was more predictive than NSI/SI phenotype for HIV replication in macrophages: is NSI/SI phenotyping sufficient?Semantic proximity Read ↗

Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entrySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.