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Article

Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4.

Journal of virology - 1 Nov 2009

Agrawal-Gamse Caroline, Lee Fang-Hua, Haggarty Beth, Jordan Andrea P O, Yi Yanjie, Lee Benhur, Collman Ronald G, Hoxie James A, Doms Robert W, Laakso Meg M

Abstract excerpt

We previously reported that a human immunodeficiency virus type 1 (HIV-1) clade B envelope protein with a severely truncated V3 loop regained function after passage in tissue culture. The adapted virus, termed TA1, retained the V3 truncation, was exquisitely sensitive to neutralization by the CD4 binding site monoclonal antibody b12 and by HIV-positive human sera, used CCR5 to enter cells, and was completely...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19692476
DOI: 10.1128/JVI.01238-09
PMCID: PMC2772790

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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