Equal levels of gp120 retention and neutralization resistance of phenotypically distinct primary human immunodeficiency virus type 1 variants upon soluble CD4 treatment.

doi:10.1128/JVI.69.1.523-527.1995

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Article

Equal levels of gp120 retention and neutralization resistance of phenotypically distinct primary human immunodeficiency virus type 1 variants upon soluble CD4 treatment.

Journal of virology - 1 Jan 1995

Groenink M, Moore J P, Broersen S, Schuitemaker H

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) variants passaged in T-cell lines, often called laboratory isolates, are potently neutralized by soluble CD4 (sCD4), whereas primary HIV-1 variants are highly resistant to sCD4 neutralization. Previously, it was demonstrated that the domain from V1 to V...

Topics

Antiviral Agents
CD4 Antigens
Cell Line
HIV Envelope Protein gp120
HIV-1
Humans
Neutralization Tests
Phenotype
Recombinant Proteins

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