Article
Molecular determinants of the V3 loop of human immunodeficiency virus type 1 glycoprotein gp120 responsible for controlling cell tropism.
The Journal of general virology - 1 Nov 1994
Chavda S C, Griffin P, Han-Liu Z, Keys B, Vekony M A, Cann A J
Abstract excerpt
We and others have identified the major determinant of cell tropism in human immunodeficiency virus type 1 (HIV-1) as the V3 loop of glycoprotein gp120. We have conducted a detailed study of two molecularly cloned isolates of HIV-1, HIVJR-CSF and HIVNL4-3, that differ in their tropism for immorta...
Topics
- Amino Acid Sequence
- Base Sequence
- CD4-Positive T-Lymphocytes
- Cells, Cultured
- Enzyme-Linked Immunosorbent Assay
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Phenotype
- Restriction Mapping
- Sequence Homology, Amino Acid
- Sequence Homology, Nucleic Acid