Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates: definition of critical amino acids involved in cell tropism.

doi:10.1128/JVI.66.11.6547-6554.1992

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Article

Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates: definition of critical amino acids involved in cell tropism.

Journal of virology - 1 Nov 1992

Chesebro B, Wehrly K, Nishio J, Perryman S

Abstract excerpt

Previous experiments indicate that the V3 hypervariable region of the human immunodeficiency virus (HIV) envelope protein influences cell tropism of infection; however, so far no consistent V3 sequence can account for macrophage or T-cell tropism. In these experiments, we studied infectious recombinant HIV clones constructed by using V3 region sequences of HIV isolates from 16 patients to search for sequences...

Topics

Amino Acid Sequence
Base Sequence
Cloning, Molecular
DNA, Recombinant
Genetic Variation
HIV
HIV Envelope Protein gp120
HIV Infections
Humans
Macrophages

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutagenesis, Site-Directed

Organ Specificity

Selection, Genetic

Sequence Homology, Amino Acid

Structure-Activity Relationship

T-Lymphocytes

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 1404602
DOI: 10.1128/JVI.66.11.6547-6554.1992
PMCID: PMC240149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1404602-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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