Article
Strain-dependent epithelial defects in mice lacking the EGF receptor.
Science (New York, N.Y.) - 14 Jul 1995
Sibilia M, Wagner E F
Abstract excerpt
Mice and cells lacking the epidermal growth factor receptor (EGFR) were generated to examine its physiological role in vivo. Mutant fetuses are retarded in growth and die at mid-gestation in a 129/Sv genetic background, whereas in a 129/Sv x C57BL/6 cross some survive until birth and even to post...
Topics
- Animals
- Cell Differentiation
- Cell Division
- Embryonic and Fetal Development
- Epithelial Cells
- ErbB Receptors
- Female
- Gene Targeting
- Hematopoiesis
- Lung
- Male
- Mice
- Mice, Inbred Strains