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Article

A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor.

The EMBO journal - 2 Feb 1998

Sibilia M, Steinbach J P, Stingl L, Aguzzi A, Wagner E F

Abstract excerpt

Mice lacking the epidermal growth factor receptor (EGFR) exhibit strain-dependent phenotypes ranging from placental to postnatal skin, lung and brain defects. After birth, all mutant mice develop a progressive neurodegeneration in the frontal cortex, olfactory bulb and thalamus, characterized by...

Topics

Animals
Astrocytes
Cell Division
Central Nervous System
ErbB Receptors
Female
Hippocampus
Hypoxia
Lung
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred CBA

Mice, Inbred Strains

Mice, Knockout

Mutation

Neovascularization, Pathologic

Source

Open in PubMed Open full text

Identifiers

PMID: 9450997
DOI: 10.1093/emboj/17.3.719
PMCID: PMC1170421

Genes

EGFR
EGF
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9450997-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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