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Article

A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor.

The EMBO journal - 2 Feb 1998

Sibilia M, Steinbach J P, Stingl L, Aguzzi A, Wagner E F

Abstract excerpt

Mice lacking the epidermal growth factor receptor (EGFR) exhibit strain-dependent phenotypes ranging from placental to postnatal skin, lung and brain defects. After birth, all mutant mice develop a progressive neurodegeneration in the frontal cortex, olfactory bulb and thalamus, characterized by massive apoptosis and upregulation of c-fos. These defects occur in a strain-independent manner, since neither rescue...

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Source

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Identifiers

PMID: 9450997
DOI: 10.1093/emboj/17.3.719
PMCID: PMC1170421

Genes

EGFR
EGF
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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