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Article

Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development.

Development (Cambridge, England) - 1 Jun 1999

Luetteke N C, Qiu T H, Fenton S E, Troyer K L, Riedel R F, Chang A, Lee D C

Abstract excerpt

Targeted mice lacking functional EGF or amphiregulin (AR) were derived and bred to the TGFalpha-knockout to generate mice lacking various combinations of the three ligands. In contrast to EGF receptor (EGFR) knockout mice, triple null mice lacking half of the EGFR ligand family were healthy and fertile, indicative of overlapping or compensatory functions among EGF family members. Nevertheless, pups born to triple...

Read the complete abstract on PubMed

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Share to Animals, Newborn
Share to Epidermal Growth Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Intercellular Signaling Peptides and Proteins

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Share to Mammary Glands, Animal

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Source

Identifiers

PMID: 10331984
DOI: 10.1242/dev.126.12.2739

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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