Placental and embryonic growth restriction in mice with reduced function epidermal growth factor receptor alleles.

doi:10.1534/genetics.109.104372

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Article

Placental and embryonic growth restriction in mice with reduced function epidermal growth factor receptor alleles.

Genetics - 1 Sept 2009

Dackor Jennifer, Caron Kathleen M, Threadgill David W

Abstract excerpt

Embryos lacking an epidermal growth factor receptor (EGFR) exhibit strain-specific defects in placental development that can result in mid-gestational embryonic lethality. To determine the level of EGFR signaling required for normal placental development, we characterized congenic strains homozygous for the hypomorphic Egfr(wa2) allele or heterozygous for the antimorphic Egfr(Wa5) allele. Egfr(wa2) homozygous...

Topics

Alleles
Animals
Animals, Newborn
Embryo, Mammalian
Female
Fetal Growth Retardation
Genes, erbB-1
Homozygote
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Transgenic
Organ Size
Placenta
Placenta Diseases
Placentation
Pregnancy
Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 19564486
DOI: 10.1534/genetics.109.104372
PMCID: PMC2746145

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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