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Article

Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart.

Development (Cambridge, England) - 1 Oct 2003

Sibilia Maria, Wagner Bettina, Hoebertz Astrid, Elliott Candace, Marino Silvia, Jochum Wolfram, Wagner Erwin F

Abstract excerpt

Mice lacking the epidermal growth factor receptor (EGFR) develop epithelial defects and a neurodegenerative disease and die within the first month of birth. By employing a conditional knock-in approach using the human EGFR cDNA mice humanised for EGFR (hEGFRKI/KI) were generated. Homozygous hEGFRKI/KI mice are viable and live up to six months. However, these mice are growth retarded and show skin and hair defects...

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Source

Identifiers

PMID: 12925580
DOI: 10.1242/dev.00664

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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