Article
Evidence of positively selected G6PD A- allele reduces risk of Plasmodium falciparum infection in African population on Bioko Island.
Molecular genetics & genomic medicine - 1 Feb 2020
Liang Xue-Yan, Chen Jiang-Tao, Ma Yan-Bo, Huang Hui-Ying, Xie Dong-De, Monte-Nguba Santiago-M, Ehapo Carlos Salas, Eyi Urbano Monsuy, Zheng Yu-Zhong, Liu Xiang-Zhi, Zha Guang-Cai, Lin Li-Yun, Chen Wei-Zhong, Zhou Xia, Lin Min
Abstract excerpt
BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) is an essential enzyme that protects red blood cells from oxidative damage. Although G6PD-deficient alleles appear to confer a protective effect of malaria, the link with clinical protection against Plasmodium infection is conflicting. METHODS: A case-control study was conducted on Bioko Island, Equatorial Guinea and further genotyping analysis used to detect...
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