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Article

X-linked G6PD deficiency protects hemizygous males but not heterozygous females against severe malaria.

PLoS medicine - 1 Mar 2007

Guindo Aldiouma, Fairhurst Rick M, Doumbo Ogobara K, Wellems Thomas E, Diallo Dapa A

Abstract excerpt

BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) is important in the control of oxidant stress in erythrocytes, the host cells for Plasmodium falciparum. Mutations in this enzyme produce X-linked deficiency states associated with protection against malaria, notably in Africa where the A- form of G6PD deficiency is widespread. Some reports have proposed that heterozygous females with mosaic populations of...

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Share to Chromosomes, Human, X
Share to Genes, X-Linked
Share to Genetic Diseases, X-Linked

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glucosephosphate Dehydrogenase

Share to Glucosephosphate Dehydrogenase Deficiency

Share to Immunity, Innate

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Source

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Identifiers

PMID: 17355169
DOI: 10.1371/journal.pmed.0040066
PMCID: PMC1820604

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Source receipt: pubmed, retrieved 7 Sept 2026.

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