Article
Identical allelic loss on chromosome 11q13 in microdissected in situ and invasive human breast cancer.
Cancer research - 1 Feb 1995
Zhuang Z, Merino M J, Chuaqui R, Liotta L A, Emmert-Buck M R
Abstract excerpt
Human breast carcinoma is thought to develop through progressive stages from atypical hyperplasias to in situ carcinoma and finally to invasive and metastatic cancer. In situ breast carcinoma consists of small, isolated neoplastic foci which cannot be selectively studied by conventional methods. In this study, we used tissue microdissection to examine the loss of heterozygosity (LOH) of chromosome 11q13 in both...
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