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Article

Insulin receptor substrate-1 regulates the transformed phenotype of BT-20 human mammary cancer cells.

Cancer research - 1 Mar 2007

Dalmizrak Ozlem, Wu An, Chen Jia, Sun Hongzhi, Utama Fransiscus E, Zambelli Diana, Tran Thai H, Rui Hallgeir, Baserga Renato

Abstract excerpt

Although originating from a human breast cancer, BT-20 cells do not form colonies in soft agar. BT-20 cells do not express insulin receptor substrate-1 (IRS-1), which is known to promote both normal and abnormal growth and to inhibit differentiation. Stable expression of IRS-1 confers to BT-20 cells the ability to form colonies in soft agar. BT-20 cells form tumors in xenografts in mice, but the size of tumors is...

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Identifiers

PMID: 17332342
DOI: 10.1158/0008-5472.CAN-06-3954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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