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Article

Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer.

The New England journal of medicine - 13 Jan 2000

Gryfe R, Kim H, Hsieh E T, Aronson M D, Holowaty E J, Bull S B, Redston M, Gallinger S

Abstract excerpt

BACKGROUND: Colorectal cancer can arise through two distinct mutational pathways: microsatellite instability or chromosomal instability. We tested the hypothesis that colorectal cancers arising from the microsatellite-instability pathway have distinctive clinical attributes that affect clinical outcome. METHODS: We tested specimens of colorectal cancer from a population-based series of 607 patients (50 years of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10631274
DOI: 10.1056/NEJM200001133420201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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