Article
The value of microsatellite instability in the detection of HNPCC families and of sporadic colorectal cancers with special biological features: an investigation on a series of 100 consecutive cases.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Aug 1998
Furlan D, Tibiletti M G, Taborelli M, Albarello L, Cornaggia M, Capella C
Abstract excerpt
BACKGROUND: Microsatellite instability (MI) is a biological characteristic of most tumors involved in hereditary non-polyposis colorectal cancer (HNPCC). This disease appears to be caused by germline mutations in mismatch repair (MMR) genes, which are responsible for repairing single base-pair mismatches. At least five human genes participate in MMR. MI also occurs in 10%-15% of sporadic colorectal cancers....
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