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Article

Effects of 5-HT receptor antagonists on seizure susceptibility and locomotor activity in DBA/2 mice.

Brain research - 21 Aug 1992

Semenova T P, Ticku M K

Abstract excerpt

The effect of antagonists of serotonin (5-HT) receptor subtypes and alpha 2-adrenoceptors was investigated on audiogenic seizures and locomotor activity in DBA/2 mice. 5HT1c receptor antagonists (mianserin and cyproheptadine), 5-HT3 receptor antagonist (zacopride) and 5-HT4 receptor antagonist (ICS 205-930) increased the latency of audiogenic seizures and decreased the severity of convulsions in young (20-27 days...

Topics

Acoustic Stimulation
Animals
Mice
Mice, Inbred DBA
Motor Activity
Phenotype
Seizures
Serotonin Antagonists
Yohimbine

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1393577
DOI: 10.1016/0006-8993(92)91580-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1393577-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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