Single point mutations of the sodium channel drastically reduce the pore permeability without preventing its gating.

doi:10.1007/BF01561134

Back to search

Article

Single point mutations of the sodium channel drastically reduce the pore permeability without preventing its gating.

European biophysics journal : EBJ - 1 Jan 1991

Pusch M, Noda M, Stühmer W, Numa S, Conti F

Abstract excerpt

1. Two mutants of the sodium channel II have been expressed in Xenopus oocytes and have been investigated using the patch-clamp technique. In mutant E387Q the glutamic acid at position 387 has been replaced by glutamine, and in mutant D384N the aspartic acid at position 384 has been replaced by a...

Topics

Animals
Base Sequence
DNA
Electric Conductivity
Female
Ion Channel Gating
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Oocytes
Permeability
Rats
Sodium Channels
Xenopus laevis

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.