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Article

Mechanistic link between lidocaine block and inactivation probed by outer pore mutations in the rat micro1 skeletal muscle sodium channel.

The Journal of physiology - 1 Nov 1998

Kambouris N G, Hastings L A, Stepanovic S, Marban E, Tomaselli G F, Balser J R

Abstract excerpt

1. Mutations that disrupt Na+ channel fast inactivation attenuate lidocaine (lignocaine)-induced use dependence; however, the pharmacological role of slower inactivation processes remains unclear. In Xenopus oocytes, tryptophan substitution in the outer pore of the rat skeletal muscle channel (micro1-W402) alters partitioning among fast- and slow-inactivated states. We therefore examined the effects of W402...

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Identifiers

PMID: 9769414
DOI: 10.1111/j.1469-7793.1998.693bd.x
PMCID: PMC2231251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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