Article
Mechanistic link between lidocaine block and inactivation probed by outer pore mutations in the rat micro1 skeletal muscle sodium channel.
The Journal of physiology - 1 Nov 1998
Kambouris N G, Hastings L A, Stepanovic S, Marban E, Tomaselli G F, Balser J R
Abstract excerpt
1. Mutations that disrupt Na+ channel fast inactivation attenuate lidocaine (lignocaine)-induced use dependence; however, the pharmacological role of slower inactivation processes remains unclear. In Xenopus oocytes, tryptophan substitution in the outer pore of the rat skeletal muscle channel (mi...
Topics
- Animals
- Electric Stimulation
- Electrophysiology
- Kinetics
- Lidocaine
- Membrane Potentials
- Muscle, Skeletal
- Mutagenesis, Site-Directed
- Mutation
- Oocytes
- Patch-Clamp Techniques
- Rats
- Sodium Channel Blockers
- Sodium Channels
- Xenopus laevis