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Article

Extracellular Iron is a Modulator of the Differentiation of Osteoclast Lineage Cells.

Calcified tissue international - 1 Mar 2016

Xie Wenjie, Lorenz Sebastian, Dolder Silvia, Hofstetter Willy

Abstract excerpt

Osteoclasts originate from the hematopoietic stem cell and share a differentiation pathway with the cells of the monocyte/macrophage lineages. Development and activation of osteoclasts, and as a consequence regulation of bone resorption, depend on two growth factors: macrophage colony-stimulating factor and receptor activator of NF-κB ligand. Furthermore, cell development and activity are modulated by a...

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Identifiers

PMID: 26615413
DOI: 10.1007/s00223-015-0087-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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