Article
Cloning and characterization of the promoter region of the mouse frizzled-related protein 4 gene.
Biological chemistry - 1 Aug 2003
Wong Vincent Kam Wai, Yam Judy Wai Ping, Hsiao W L Wendy
Abstract excerpt
Frizzled-related protein (Frp) is a newly identified family of secreted proteins involved in the Wnt signaling pathway. To date, little is known about the underlying mechanisms regulating Frp expression. In this study the promoter region of mouse frizzled related protein 4 (sFrp4) gene was cloned, sequenced, and analyzed using transient reporter assays along with site-directed mutagenesis. Two clusters of...
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