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Article

Tax-dependent displacement of nucleosomes during transcriptional activation of human T-cell leukemia virus type 1.

The Journal of biological chemistry - 12 May 2006

Lemasson Isabelle, Polakowski Nicholas J, Laybourn Paul J, Nyborg Jennifer K

Abstract excerpt

The human T-cell leukemia virus type 1 (HTLV-1) is integrated into the host cell DNA and assembled into nucleosomes. Within the repressive chromatin environment, the virally encoded Tax protein mediates the recruitment of the coactivators CREB-binding protein/p300 to the HTLV-1 promoter, located within the long terminal repeats (LTRs) of the provirus. These proteins carry acetyltransferase activity that is...

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Source

Identifiers

PMID: 16547351
DOI: 10.1074/jbc.M512193200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tax-dependent displacement of nucleosomes during transcriptional activation of human T-cell leukemia virus type 1.PMID 16547351Read ↗

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