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Article

Herpes simplex virus virion host shutoff protein requires a mammalian factor for efficient in vitro endoribonuclease activity.

Journal of virology - 1 Feb 2001

Lu P, Jones F E, Saffran H A, Smiley J R

Abstract excerpt

The virion host shutoff protein (vhs) of herpes simplex virus (HSV) triggers global shutoff of host protein synthesis and accelerated mRNA turnover during virus infection and induces endoribonucleolytic cleavage of exogenous RNA substrates when it is produced in a rabbit reticulocyte (RRL) in vitro translation system. Although vhs induces RNA turnover in the absence of other HSV gene products, it is not yet known...

Topics

Animals
Endoribonucleases
Phenotype
Promoter Regions, Genetic
RNA, Messenger
Rabbits
Ribonucleases
Saccharomyces cerevisiae
Simplexvirus
Viral Proteins

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Identifiers

PMID: 11152490
DOI: 10.1128/JVI.75.3.1172-1185.2001
PMCID: PMC114023

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Herpes simplex virus virion host shutoff protein requires a mammalian factor for efficient in vitro endoribonuclease activity.PMID 11152490Read ↗

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