Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Herpes simplex virus virion host shutoff protein requires a mammalian factor for efficient in vitro endoribonuclease activity.

Journal of virology - 1 Feb 2001

Lu P, Jones F E, Saffran H A, Smiley J R

Abstract excerpt

The virion host shutoff protein (vhs) of herpes simplex virus (HSV) triggers global shutoff of host protein synthesis and accelerated mRNA turnover during virus infection and induces endoribonucleolytic cleavage of exogenous RNA substrates when it is produced in a rabbit reticulocyte (RRL) in vitro translation system. Although vhs induces RNA turnover in the absence of other HSV gene products, it is not yet known...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoribonucleases
Share to Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Rabbits

Share to Ribonucleases

Share to RNA, Messenger

Share to Saccharomyces cerevisiae

Share to Simplexvirus

Share to Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 11152490
DOI: 10.1128/JVI.75.3.1172-1185.2001
PMCID: PMC114023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Herpes simplex virus virion host shutoff protein requires a mammalian factor for efficient in vitro endoribonuclease activity.PMID 11152490Read ↗

mRNA Decay during Herpesvirus Infections: Interaction between a Putative Viral Nuclease and a Cellular Translation FactorSemantic proximity Read ↗

Mutational analysis of the herpes simplex virus virion host shutoff protein: evidence that vhs functions in the absence of other viral proteins.Semantic proximity Read ↗

The herpes simplex virus host shutoff (vhs) RNase limits accumulation of double stranded RNA in infected cells: Evidence for accelerated decay of duplex RNASemantic proximity Read ↗

Isolation of a herpes simplex virus type 1 mutant with a deletion in the virion host shutoff gene and identification of multiple forms of the vhs (UL41) polypeptide.Semantic proximity Read ↗

Dysregulated metabolism of the late herpes simplex virus 1 transcriptome through the vhs-VP22 axis uncouples virus cytopathic effect and virus productionSemantic proximity Read ↗

Nuclear-cytoplasmic compartmentalization of the herpes simplex virus 1 infected cell transcriptome is co-ordinated by the viral endoribonuclease vhs and cofactors to facilitate the translation of late proteinsSemantic proximity Read ↗

Dissecting Herpes Simplex Virus 1-Induced Host Shutoff at the RNA LevelSemantic proximity Read ↗

Pathogenesis of herpes simplex virus type 2 virion host shutoff (vhs) mutants.Semantic proximity Read ↗

Dissecting HSV-1-induced host shut-off at RNA levelSemantic proximity Read ↗

Herpes simplex virus virion host shutoff (vhs) activity alters periocular disease in mice.Semantic proximity Read ↗

mRNA Decay during Herpes Simplex Virus (HSV) Infections: Mutations That Affect Translation of an mRNA Influence the Sites at Which It Is Cleaved by the HSV Virion Host Shutoff (Vhs) ProteinSemantic proximity Read ↗

Dysregulated nuclear export of the late herpes simplex virus 1 transcriptome through the vhs-VP22 axis uncouples virus cytopathic effect and virus productionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.