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Article

Lambda Interferon Is the Predominant Interferon Induced by Influenza A Virus Infection <i>In Vivo</i>

26 Aug 2010

Abstract excerpt

The type I alpha/beta interferons (IFN-α/β) are known to play an important role in host defense against influenza A virus infection, but we have now discovered that the recently identified type III IFNs (IFN-λ) constitute the major response to intranasal infection with this virus. Type III IFNs were present at much higher levels than type I IFNs in the lungs of infected mice, and the enhanced susceptibility of...

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PMID: 20739515
DOI: 10.1128/jvi.01703-09

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