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Article

Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon.

Journal of virology - 1 Apr 2000

Deonarain R, Alcamí A, Alexiou M, Dallman M J, Gewert D R, Porter A C

Abstract excerpt

We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not prime its own expression.

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Identifiers

PMID: 10708458
DOI: 10.1128/jvi.74.7.3404-3409.2000
PMCID: PMC111842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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