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Article

Hematopoietic cell–derived interferon controls viral replication and virus-induced disease

30 Oct 2008

Abstract excerpt

Type I interferon (IFN-I) strongly inhibits viral replication and is a crucial factor in controlling virus infections and diseases. Cellular activation through pattern recognition receptors induces interferon production in a wide variety of hematopoietic and nonhematopoietic cell types, including dendritic cells, fibroblasts, hepatocytes, and cells of neuronal origin. The relative contribution of hematopoietic...

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Identifiers

PMID: 18971424
DOI: 10.1182/blood-2007-10-117861

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