Article
Genomic imprinting in the rat: linkage of Igf2 and H19 genes and opposite parental allele-specific expression during embryogenesis.
Genomics - 15 Oct 1997
Overall M, Bakker M, Spencer J, Parker N, Smith P, Dziadek M
Abstract excerpt
Igf2 and H19 are closely linked imprinted genes in both mice and humans that are expressed from opposite parental alleles. In this study we demonstrate that these two genes are also closely linked in the rat, with the H19 gene mapping to within 145 kb of Igf2 on rat chromosome 1. We identified po...
Topics
- Alleles
- Animals
- Base Sequence
- Crosses, Genetic
- DNA Primers
- Female
- Gene Expression Regulation, Developmental
- Genetic Linkage
- Genomic Imprinting
- Humans
- Insulin-Like Growth Factor II
- Male
- Mice
- Muscle Proteins
- Polymerase Chain Reaction
- RNA, Long Noncoding
- RNA, Untranslated
- Rats