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Article

High-grade dysplasia associated with fundic gland polyposis in a familial adenomatous polyposis patient, with special reference to APC mutation profiles.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2004

Sekine Shigeki, Shimoda Tadakazu, Nimura Satoshi, Nakanishi Yukihiro, Akasu Takayuki, Katai Hitoshi, Gotoda Takuji, Shibata Tatsuhiro, Sakamoto Michiie, Hirohashi Setsuo

Abstract excerpt

We report a patient with familial adenomatous polyposis who developed high-grade dysplasia against a background of fundic gland polyposis. Two large high-grade dysplasia lesions were found in the gastric body, where numerous fundic gland polyps were present. In both lesions, the dysplastic epithelium covered non-neoplastic oxyntic glands that occasionally exhibit cystic changes. A genetic analysis for APC...

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PMID: 15494708
DOI: 10.1038/modpathol.3800178

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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