Article
Mice develop normally without the H1(0) linker histone.
Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 1995
Sirotkin A M, Edelmann W, Cheng G, Klein-Szanto A, Kucherlapati R, Skoultchi A I
Abstract excerpt
H1 histones bind to the linker DNA between nucleosome core particles and facilitate the folding of chromatin into a 30-nm fiber. Mice contain at least seven nonallelic subtypes of H1, including the somatic variants H1a through H1e, the testis-specific variant H1t, and the replacement linker histone H1(0). H1(0) accumulates in terminally differentiating cells from many lineages, at about the time when the cells...
Topics
- Animals
- Base Sequence
- Chimera
- Chromatin
- DNA Primers
- Embryo, Mammalian
- Female
- Genetic Variation
- Genotype
- Histones
- Homozygote
- Kidney