Article
Saccharomyces cerevisiae linker histone Hho1p functionally interacts with core histone H4 and negatively regulates the establishment of transcriptionally silent chromatin.
The Journal of biological chemistry - 9 Jan 2009
Yu Qun, Kuzmiak Holly, Zou Yanfei, Olsen Lars, Defossez Pierre-Antoine, Bi Xin
Abstract excerpt
Saccharomyces cerevisiae linker histone Hho1p is not essential for cell viability, and very little is known about its function in vivo. We show that deletion of HHO1 (hho1Delta) suppresses the defect in transcriptional silencing caused by a mutation in the globular domain of histone H4. hho1Delta also suppresses the reduction in HML silencing by the deletion of SIR1 that is involved in the establishment of silent...
Topics
- Chromatin
- Gene Deletion
- Gene Silencing
- Histones
- Mutation
- Protein Binding
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Silent Information Regulator Proteins, Saccharomyces cerevisiae
- Transcription, Genetic