Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

H1 linker histones are essential for mouse development and affect nucleosome spacing in vivo.

Molecular and cellular biology - 1 Jul 2003

Fan Yuhong, Nikitina Tatiana, Morin-Kensicki Elizabeth M, Zhao Jie, Magnuson Terry R, Woodcock Christopher L, Skoultchi Arthur I

Abstract excerpt

Most eukaryotic cells contain nearly equimolar amounts of nucleosomes and H1 linker histones. Despite their abundance and the potential functional specialization of H1 subtypes in multicellular organisms, gene inactivation studies have failed to reveal essential functions for linker histones in vivo. Moreover, in vitro studies suggest that H1 subtypes may not be absolutely required for assembly of chromosomes or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Chromatin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromatography, High Pressure Liquid

Share to Chromosomes

Share to Histones

Share to Micrococcal Nuclease

Share to Nucleosomes

Share to Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 12808097
DOI: 10.1128/MCB.23.13.4559-4572.2003
PMCID: PMC164858

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

H1 linker histones are essential for mouse development and affect nucleosome spacing in vivo.PMID 12808097Read ↗

Individual somatic H1 subtypes are dispensable for mouse development even in mice lacking the H1(0) replacement subtype.Semantic proximity Read ↗

Mice develop normally without the H1(0) linker histone.Semantic proximity Read ↗

Histone H1 null vertebrate cells exhibit altered nucleosome architecture.Semantic proximity Read ↗

Rapid H1 linker histone transitions following fertilization or somatic cell nuclear transfer: evidence for a uniform developmental program in miceSemantic proximity Read ↗

A genetic screen and transcript profiling reveal a shared regulatory program for Drosophila linker histone H1 and chromatin remodeler CHD1.Semantic proximity Read ↗

Normal Spermatogenesis in Mice Lacking the Testis-Specific Linker Histone H1tSemantic proximity Read ↗

Depletion of human histone H1 variants uncovers specific roles in gene expression and cell growth.Semantic proximity Read ↗

Biparental contributions of the H2A.B histone variant control embryonic development in mice.Semantic proximity Read ↗

Compensatory replacement of the BigH1 variant histone by canonical H1 supports normal embryonic development in DrosophilaSemantic proximity Read ↗

Chromatin condensing functions of the linker histone C-terminal domain are mediated by specific amino acid composition and intrinsic protein disorder.Semantic proximity Read ↗

Histone H1 diversity: bridging regulatory signals to linker histone function.Semantic proximity Read ↗

Histone variant H3.3 maintains a decondensed chromatin state essential for mouse preimplantation developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.