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Article

Consideration of the liver of embryonic lacZ transgenic mice as an analogue of the mouse coat colour spot test: preliminary data and technical problems.

Mutation research - 1 Jul 1995

Morrison V, Tinwell H, Ashby J

Abstract excerpt

Pregnant lacZ+ transgenic mice (Muta Mouse) were treated with ENU (25 mg/kg) by oral gavage on day 10.5 of pregnancy. This dose of ENU is the optimal dose observed by other investigators for activity in the mouse coat colour spot test. Day 10.5 of pregnancy represents the stage when the embryonic liver first becomes visually discernable. By day 15.5, when the maternal and embryonic livers were analysed for lacZ-...

Topics

Animals
DNA Mutational Analysis
Ethylnitrosourea
Female
Lac Operon
Liver
Mice
Mice, Transgenic
Mutagenicity Tests
Mutation
Pregnancy

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Source

Identifiers

PMID: 7603492
DOI: 10.1016/0027-5107(95)00022-b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7603492-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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