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Article

Simultaneous induction of mutagenic and cancerogenic effects in T x HT mice with transplacental ethylnitrosourea treatment.

Teratogenesis, carcinogenesis, and mutagenesis - 1 Jan 1990

Schmahl W, Neuhäuser-Klaus A, Leierseder-Bauer M, Luz A

Abstract excerpt

The relationship between mutagenesis and carcinogenesis was investigated in T x HT crossbred mice using diaplacental application of ethylnitrosourea (ENU) at different stages of embryonal development. Mutagenesis was detected by induction of coat color spots, and the carcinogenic response was investigated in a long-term follow-up study of the F1-generation. The animals were particularly sensitive to induction of...

Topics

Animals
Carcinogens
Ethylnitrosourea
Female
Male
Maternal-Fetal Exchange
Mice
Mosaicism
Mutagens
Mutation
Neoplasms, Experimental
Pregnancy

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Identifiers

PMID: 1980033
DOI: 10.1002/tcm.1770100404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1980033-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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