Article
The paternal genome in mouse zygotes is less sensitive to ENU mutagenesis than the maternal genome.
Mutation research - 1 May 1991
Russell L B, Bangham J W
Abstract excerpt
The two parental genomes lie separate within the zygote and may be differentially affected by environmental influences. We have shown earlier (Russell et al., 1988) that the maternal genome within the mouse zygote is exquisitely sensitive to the induction of point mutations by N-ethyl-N-nitrosourea (ENU), and that the initial lesion probably occurs in one strand of the DNA. The present experiment measured...
Topics
- Animals
- Cell Survival
- DNA
- Ethylnitrosourea
- Female
- Gene Expression
- Male
- Mice
- Mutation
- Oocytes
- Pregnancy
- Sex Factors
- Spermatozoa