Article
A preliminary assessment of the toxic and mutagenic potential of steroidal alkaloids in transgenic mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Mar 1995
Crawford L, Myhr B
Abstract excerpt
Impregnated CD2 transgenic mice, which contain multiple copies of a lambda gt10lacZ construct integrated into the genome of each cell, were given a predetermined estimated maximum tolerated dose of several steroidal alkaloids: Solanum glycoalkaloids from potato, alpha-chaconine and alpha-solanine...
Topics
- Alkaloids
- Animals
- Diosgenin
- Embryonic and Fetal Development
- Female
- Gene Expression Regulation, Developmental
- Lac Operon
- Liver
- Mice
- Mice, Inbred BALB C
- Mice, Transgenic
- Mutation
- Pregnancy
- Solanaceous Alkaloids
- Solanine
- Solanum tuberosum
- Teratogens
- Tretinoin