Embryonic mutation as a possible cause of in utero carcinogenesis in mice revealed by postnatal treatment with 12-O-tetradecanoylphorbol-13-acetate.

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Article

Embryonic mutation as a possible cause of in utero carcinogenesis in mice revealed by postnatal treatment with 12-O-tetradecanoylphorbol-13-acetate.

Cancer research - 1 Apr 1990

Nomura T, Nakajima H, Hatanaka T, Kinuta M, Hongyo T

Abstract excerpt

Although in utero irradiation at early stages induced a high incidence of somatic mutations at coat color genes in the embryos of a specified tester strain (PT x HT F1) of mice, it was not carcinogenic by itself. However, in utero-irradiated animals did develop skin tumors and hepatomas (but not...

Topics

Animals
Dose-Response Relationship, Radiation
Embryo, Mammalian
Female
Liver Neoplasms, Experimental
Mice
Mutation
Neoplasms, Radiation-Induced
Pregnancy
Skin Neoplasms
Tetradecanoylphorbol Acetate
X-Rays

Source

Open in PubMed

Identifiers

PMID: 2317804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2317804-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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