Article
Genomic variation in pancreatic ion channel genes in Japanese type 2 diabetic patients.
Diabetes/metabolism research and reviews - 1 Jan 2000
Yamada Y, Kuroe A, Li Q, Someya Y, Kubota A, Ihara Y, Tsuura Y, Seino Y
Abstract excerpt
BACKGROUND: Many genetic diseases are caused by mutations in ion channel genes. Because type 2 diabetes is characterized by pancreatic beta-cell insensitivity to glucose, the genes responsible for glucose metabolism and calcium signaling in pancreatic beta-cells are candidate type 2 diabetes susceptibility genes. METHODS: We have examined genomic variations in two ion channel genes relevant to the molecular...
Topics
- Alleles
- Amino Acid Substitution
- Asian People
- Calcium Channels
- Diabetes Mellitus, Type 2
- Genetic Variation
- Genotype
- Humans
- Islets of Langerhans
- Japan
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Single-Stranded Conformational