Article
Modulation of a recombinant glycine transporter (GLYT1b) by activation of protein kinase C.
Journal of neurochemistry - 1 Nov 1995
Sato K, Adams R, Betz H, Schloss P
Abstract excerpt
Treatment of human embryonic kidney cells (HEK 293 cells) expressing the mouse glycine transporter 1 (GLYT1b) with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) decreased specific [3H]glycine uptake. This down-regulation resulted from a reduction of the maximal transp...
Topics
- Amino Acid Transport Systems, Neutral
- Carrier Proteins
- Cell Line
- Enzyme Activation
- Glycine
- Glycine Plasma Membrane Transport Proteins
- Humans
- Membrane Potentials
- Mutation
- Protein Kinase C
- Recombinant Proteins
- Sodium-Hydrogen Exchangers
- Tetradecanoylphorbol Acetate