Article

Chloride-dependent conformational changes in the GlyT1 glycine transporter

2020-08-20

Abstract excerpt

The human GlyT1 glycine transporter requires chloride for its function. However, the mechanism by which Cl - exerts its influence is unknown. To examine the role that Cl - plays in the transport cycle, we measured the effect of Cl - on both glycine binding and conformational changes. The ability of glycine to displace the high-affinity radioligand [ 3 H]CHIBA-3007 required Na + and was potentiated over 1000-f...

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Literature Corpus work: 6cbe4543-0369-575a-b77f-cbf5901f472d
DOI: 10.1101/2020.08.20.259572

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