Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular basis for differential glycine transporters sensitivity to sanguinarine.

Toxicology letters - 3 Aug 2012

Jursky Frantisek, Baliova Martina, Mihalikova Andrea

Abstract excerpt

We previously demonstrated that glycine transporters GlyT1 and GlyT2 are differentially affected by toxic benzophenanthridine alkaloids. Using a combination of homology modeling, knowledge of the sensitivity of sanguinarine to sulfhydryl reagents and site directed mutagenesis we show here that the increased sensitivity of human GlyT1c to sanguinarine is abolished by the mutation of only cysteine 475. Inhibition...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Infective Agents
Share to Cell Membrane Permeability
Share to Cysteine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Isoquinolines

Share to Mutagenesis, Site-Directed

Share to Mutation

Share to Protein Structure, Tertiary

Source

Identifiers

PMID: 22705056
DOI: 10.1016/j.toxlet.2012.06.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular basis for differential glycine transporters sensitivity to sanguinarine.PMID 22705056Read ↗

Discovery of New Classes of Glycine transporter 2 (GlyT2) Inhibitors and Study of GlyT2 Selectivity by Combination of Novel Structural Based Virtual Screening Approach and Free Energy Perturbation (FEP+) CalculationsSemantic proximity Read ↗

Chloride-dependent conformational changes in the GlyT1 glycine transporterSemantic proximity Read ↗

Molecular basis for substrate discrimination by glycine transporters.Semantic proximity Read ↗

Transmembrane domain 8 of the {gamma}-aminobutyric acid transporter GAT-1 lines a cytoplasmic accessibility pathway into its binding pocket.Semantic proximity Read ↗

Mutations in the GlyT2 gene (SLC6A5) are a second major cause of startle disease.Semantic proximity Read ↗

Mutations in the gene encoding GlyT2 (SLC6A5) define a presynaptic component of human startle disease.Semantic proximity Read ↗

Hyperekplexia-associated mutations in the neuronal glycine transporter 2.Semantic proximity Read ↗

Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.Semantic proximity Read ↗

Molecular mechanisms of glycine transporter GlyT2 mutations in startle disease.Semantic proximity Read ↗

The role of the glycine triad in human glutathione synthetase.Semantic proximity Read ↗

Characterisation of the influence of genetic variations on the enzyme activity of a recombinant human glycine N-acyltransferase.Semantic proximity Read ↗

Functional consequences of sulfhydryl modification of the γ-aminobutyric acid transporter 1 at a single solvent-exposed cysteine residue.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.