Early replication block of human immunodeficiency virus type 1 in monkey cells

doi:10.1099/0022-1317-76-11-2723

Article

Early replication block of human immunodeficiency virus type 1 in monkey cells

1 Nov 1995

Abstract excerpt

The genetic and functional basis of the replication-defective nature of human immunodeficiency virus type 1 (HIV-1) in monkey cells was studied. By the generation and characterization of chimeras between HIV-1 and simian immunodeficiency virus, the sequence encompassing the 3' half of the long terminal repeat, gag and pol genes of HIV-1 was found to be responsible for the growth restriction. Early and late phases...

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