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Article

Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cells

1 Jul 1991

Abstract excerpt

We constructed five chimeric clones between human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIVMAC) and four SIVMAC mutants by recombinant DNA techniques. Three chimeric clones and all mutants with an alteration in either the vif, vpx, vpr, or nef gene were infectious to human CD4-positive cell lines. The susceptibility of macaque monkey peripheral blood mononuclear cells (PBMC) to...

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PMID: 2041078
DOI: 10.1128/jvi.65.7.3514-3520.1991

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